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Research

Fellows have opportunities to learn and get involved in both clinical and basic science research. They can do research with the faculty inside and outside of the division of neonatology. The research interests of the faculty vary from basic science research in infection/ immunology to cerebral circulation and physiology. Varied clinical science projects are also underway, and we have been part of several multicenter trials.

The NICU also has a database for the past 30 years which makes it easy for faculty and fellows to obtain background information for clinical projects.

Division of Neonatology Recent Publications 

Basic Science and Translational Research

  1. Mims T, Al Abdallah Q, Stewart J, Watts S, White C, Rousselle T, Bajwa A, Han JC, Willis KA, Pierre JF (Corresponding). The gut mycobiome is shaped by the environment and shapes metabolic outcomes in response to diet. Commun Biol. 2021 Mar 5;4(1):281.
  2. Shukla PK, Meena AS, Dalal K, Canelas C, Samak G, Pierre JF, Rao RK. Chronic Stress and Corticosterone Exacerbate Alcohol-Induced Tissue Injury in the Gut-Liver-Brain Axis. Scientific Reports. 2021 In Press.   
  3. Shukla P, Delotterie DF, Xiao J, Pierre JF, Rao RK, McDonald MP, Khan MM. Alternation in gut-microbial-inflammasome-brain axis in a mouse model of Alzheimer’s disease. Cells. 2021;10(4):799. 
  4. Fedinac AL, Liu J, Zhang r, Harsono M, Pourcyrous M, Parefenova H. The cold receptor TRPM8 activation leads to attenuation of endothelium-dependent cerebral vascular functions during head cooling. Journal of Cerebral blood flow and metabolism, J Cereb Blood Flow Metab 2021 May 20;271678X211018035
  5. Pierre JF, Phillips GJ, Rendina DN, Lyte M, Coe CL, Gosain A. Lyticase Digestion Facilitates Mycobiome Sequencing without Disrupting Microbiome Fidelity. J Surg Research. 2021 Jun 26;267:336-341
  6. Pingili AK, Chaib M, Sipe LM, Miller EJ, Teng B, Sharma R, Yarbro JR, Asemota S, Al Abdallah Q, Mims TS, Marion TN, Daria D, Sekhri R, Hamilton AM, Troester MA, Jo H, Choi HY, Hayes DN, Cook KL, Narayanan R, Pierre JF, Makowski L. Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. 2021 Jun 22;35(12):109285
  7. TGR5 signaling mitigates parenteral nutrition-associated liver disease. Willis KA, Gomes CK, Rao P, Micic D, Moran ER 3rd, Stephenson E, Puchowicz M, Al Abdallah Q, Mims TS, Gosain A, Yin D, Talati AJ, Chang EB, Han JC, Pierre JF. Am J Physiol Gastrointest Liver Physiol. 2020 Feb 1;318(2):G322-G335. doi: 10.1152/ajpgi.00216.2019. Epub 2020 Jan 6. PMID: 31905022
  8. Xu R, Zhu C, Pierre JF, Yin DP. Gastric Bypass Improves Obesity and Glucose Tolerance Independent of Gastric Pouch Size. Obes Surg. 2020 May;30(5):1635-1641. doi: 10.1007/s11695-020-04403-9. PMID: 31927685
  9. van der Merwe M, Sharma S, Caldwell JL, Smith NJ, Gomes CK, Bloomer RJ, Buddington RK, Pierre JF. Time of Feeding Alters Obesity-Associated Parameters and Gut Bacterial Communities, but Not Fungal Populations, in C57BL/6 Male Mice. Curr Dev Nutr. 2020 Jan 3;4(2):nzz145. doi: 10.1093/cdn/nzz145. eCollection 2020 Feb. PMID: 32025616
  10. Sipe LM, Chaib M, Pingili AK, Pierre JF, Makowski L. Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity. Immunol Rev. 2020 May;295(1):220-239. doi: 10.1111/imr.12856. PMID: 32320071
  11. Pierre JF. Reply to "Letter to Editor: Takeda-G Protein Receptor-5 signaling mitigates parenteral nutrition-associated liver disease: public health impact". 
  12. Fuyi Xu, Jun Gao, Undral Munkhsaikhan, Ning Li, Qingqing Gu, Joseph F. Pierre, Athena Starlard-Davenport, Jeffrey A. Towbin, Yan Cui, Enkhsaikhan Purevjav, Lu Lu The genetic dissection of Ace2 expression variation in the heart of murine genetic reference population. Frontiers in Cardiovascular Medicine, section Cardiovascular Genetics and Systems Medicine (accepted Sept 2, 2020)
  13. Satapathy SK, Banerjee P, Pierre JF, Higgins D, Dutta S, Heda R, Khan SD, Mupparaju VK, Mas V, Nair S, Eason JD, Kleiner De, Maluf DG. Characterization of Gut Microbiome in Liver Transplant Recipients with Non-Alcoholic Steatohepatitis. Transplantation Direct. In Press

Clinical Research

  1. Sakaria R, Zaveri P. Neonatal Gastric Perforation: 14-year Experience from a Tertiary Neonatal Intensive Care Unit. Accepted for publication in Am J Perinatology, June 2021
  2. Sakaria RP, Mostavi R, Stephen M, Ward JC, Pivnick E, Talati AJ. Kagami-Ogata syndrome: case series and review of literature AJP Rep 2021 Mar;11(2):e65-e75.
  3. Desai J, Key L, Blair A, Gaston P, Talati AJ. The Danger of Diazoxide in the Neonatal Intensive Care Unit DOI:10.1177/20420986211011338. Accepted for publication in Therapeutic Advances in Drug Safety, March 2021. Published May 18, Volume 12, page 1-8. 
  4. Zaveri P, Upadhyay K, Talati AJ. Use of vasopressors in extremely preterm infants in first week of life. Accepted for publication, American Journal of Perinatology, March 202, Published Am J Perinatol. 2021 May 14.
  5. Oscar Herrera, Catherine Crill, Luke Parish, Ramesh Krishnan and Michael L Christensen Use of a Mixed-Oil Lipid Emulsion in Infants with Intestinal Failure Associated Liver Disease who were Receiving a Soybean Oil Emulsion. 10(4): 14-21. EC Pediatrics, April 2021
  6. Harsono M, Yanishevski D, Pourcyrous M Congenital Perineal Groove Defect in Monozygotic Twin Infants: A Literature Review. AJP Rep. 2021 Jan;11(1):e54-e57. doi: 10.1055/s-0041-1727145. Epub 2021 Mar 31.PMID: 33815912 
  7. Seabrook R, Grover T, Rintoul N, Weems M, Keene S, Brozanski B, DiGenronimo R, Haberman B, Hedrick H, Gien J, Ali N, Chapman R, Daniel J, Harrison A, Johnson Y, Porta N, Uhing M, Zaniletti I, Murthy K. Treatment of Pulmonary Hypertension During Initial Hospitalization in a Multicenter Cohort of Infants with Congenital Diaphragmatic Hernia (CDH). Journal of Perinatology. Epub ahead of print, March 1, 2021. PMID: 33649432. DOI: 10.1038/s41372-021-00923-z.
  8. Grover T, MF Weems, B Brozanski, JM Daniel, B Haberman, NE Rintoul, A Walden, HL Hedrick, B Mahmood, RB Seabrook, K Murthy, I Zaniletti, S Keene. Central line utilization and complications in infants with congenital diaphragmatic hernia (CDH). American Journal of Perinatology. Epub ahead of print, Feb 3, 2021. PMID: 33535242. 
  9. Agarwal P, Natarajan G, Sullivan K, Rao R, Rintoul N, Zaniletti I, Keene S, Mietzsch U, Massaro A, Billimoria A, Dirnberger D, Hamrick S, Seabrook R, Weems M, Cleary J, Gray B, DiGeronimo R. Venovenous Versus Venoarterial Extracorporeal Membrane Oxygenation Among Infants with Hypoxic Ischemic Encephalopathy: Is There a Difference in Outcome? J Perinatol 2021 May 19
  10. Weems MF, Grover TR, Seabrook R, DiGenronimo R, Gien J, Keene S, Rintoul N, Daniel JM, Johnson Y, Guner Y, Zaniletti I, Murthy K. Analgesia, Sedation, and Neuromuscular Blockade in Infants with Congenital Diaphragmatic Hernia. Am J of Perinatol. 2020 May 27
  11. Turner S, Davidson J, Elabiad MT. Changes in Urinary Kidney Injury Molecule-1 Levels after Blood Transfusions in Preterm Infants. Accepted for publication in Sci Rep. 2021 Jun 3;11(1):11690. 
  12. Lamba V, Winners O, Fort P. Early High-Dose Caffeine Improves Respiratory Outcomes in Preterm Infants. Children (Basel). 2021;8(6):501. 2021 Jun 13. doi:10.3390/children8060501
  13. Davidson JM, Ferguson J, Ivey E, Philip R, Weems MF, Talati AJ. J Perinatol. 2020 May 21. doi: 10.1038/s41372-020-0694-1. Online ahead of print. PMID: 32439957 A randomized trial of intravenous acetaminophen versus indomethacin for treatment of hemodynamically significant PDAs in VLBW infants. 
  14. Estimated fetal weight and severe neonatal outcomes in preterm prelabor rupture of membranes. Duncan JR, Dorsett KM, Aziz MM, Bursac Z, Cleves MA, Talati AJ, Schenone MH, Meyer NL, Mari G. J Perinat Med. 2020 Jul 6:/j/jpme.ahead-of-print/jpm-2019-0474/jpm-2019-0474.xml. doi: 10.1515/jpm-2019-0474. Online ahead of print. PMID: 32621734
  15. Comparison of institutional guidelines with established early onset sepsis risk calculator in reducing antibiotic use in an inner-city NICU in US. Benaim EH, Upadhyay K,Talati AJ. J Glob Antimicrob Resist. 2020 Jun;21:124-129. doi: 10.1016/j.jgar.2020.03.015. Epub 2020 Mar 29. PMID: 32234556
  16. Davidson J, Elabiad MT. A Simple Intervention to Decrease Nutrient Losses in Continuous Feeds With Human Milk. J Pediatr Gastroenterol Nutr. 2020 Apr;70(4):e81-e83. doi: 10.1097/MPG.0000000000002609. PMID: 31899735
  17. Lamba V, D'souza S, Carafa C, Zepf A, Bassel CL, Gutierrez M, Balakrishnan M. Standardizing the approach to late onset sepsis in neonates through antimicrobial stewardship: a quality improvement initiative. J Perinatol. 2020 Sep;40(9):1433-1440. doi: 10.1038/s41372-019-0577-5. Epub 2020 Jan 6. PMID: 31907396
  18. Willis KA, Postnikoff CK, Freeman A, Rezonzew G, Nichols K, Gaggar A, Lal CV.The closed eye harbours a unique microbiome in dry eye disease. Sci Rep. 2020 Jul 21;10(1):12035. doi: 10.1038/s41598-020-68952-w. PMID: 32694705
  19. Willis KA, Peters BM, Pierre JF. A stable cutaneous mycobiome exists from birth. Pediatr Res. 2020 Aug;88(2):153-154. doi: 10.1038/s41390-020-0959-6. Epub 2020 May 14. PMID: 32408339 No abstract available.
  20. Pierre JF, Akbilgic O, Smallwood H, Cao X, Fitzpatrick EA, Pena S, Furmanek SP, Ramirez JA, Jonsson CB. Discovery and predictive modeling of urine microbiome, metabolite and cytokine biomarkers in hospitalized patients with community acquired pneumonia. Sci Rep. 2020 Aug 7;10(1):13418. doi: 10.1038/s41598-020-70461-9. PMID: 32770049
  21. Harding JN, Siefker D, Vu L, You D, DeVincenzo J, Pierre JF, Cormier SA. Altered gut microbiota in infants is associated with respiratory syncytial virus disease severity. BMC Microbiol. 2020 Jun 1;20(1):140. doi: 10.1186/s12866-020-01816-5. PMID: 32487019
  22. Upadhyay K, Vallarino DA, Talati AJ. Outcomes of neonates with tracheostomy secondary to bronchopulmonary dysplasia. BMC Pediatr. 2020 Sep 1;20(1):414. doi: 10.1186/s12887-020-02324-1. PMID: 32873254
  23. Philip R, Waller BR, Chilakala S, Graham B, Stecchi N, Apalodimas L, Cunningham J, Washington K, Sathanandam S. Hemodynamic and clinical consequences of early versus delayed closure of patent ductus arteriosus in extremely low birth weight infants.  J Perinatol. 2020 Aug 13. doi: 10.1038/s41372-020-00772-2. Online ahead of print. PMID: 32792636
  24. Philip R, Lamba V, Talati A, Sathanandam SK. Pulmonary hypertension with prolonged patency of ductus arteriosus in preterm infants. Children 2020, 7(9), 139; https://doi.org/10.3390/children7090139
  25. Tucker A, Huang EY, Peredo J, Weems MF. Pilot Study of Sham Feeding in Post-Operative Neonates. American Journal of Perinatology. Epub ahead of print, October 20, 2020. DOI: 10.1055/s-0040-1718881
May 26, 2022